Royal Air Force Typhoon FGR4s have operated alongside French warplanes in a coordinated attack on an underground arms cache in Syrian territory used by the IS group, according to the UK's MoD.
The location, located using intelligence, was thought to be containing munitions and bombs, the release indicated, and was situated in mountainous terrain just north of the ancient city of Palmyra in Syria's central region.
"Our fighter planes utilized precision-guided Paveway IV munitions to target a series of entry passages leading to the facility... initial indications suggest the target was engaged successfully," the MoD said.
There was no sign of any civilian casualties in the strike on Saturday evening and every plane involved made a safe return, the defence officials confirmed.
The British jets were assisted by a Voyager refuelling tanker.
IS - referred to as Daesh - enforced militant control over parts of Iraq and Syria before its territorial defeat in 2019.
"This action shows British leadership, and commitment to stand shoulder to shoulder with our partners, to stamp out any resurgence of Daesh and their violent and radical beliefs in the area," Britain's Defence Chief John Healey stated.
UK warplanes have carried out overwatch operations over Syrian airspace to "forestall any attempted resurgence" of the group after its military defeat at the Baghuz confrontation in the year 2019, the MoD reported.
"I extend gratitude to all the members of British forces participating in this operation for their professionalism and their courage," Healey commented. "They were among numerous UK service members stationed over the holidays. This mission, to eliminate terrorist threats who endanger our safety, highlights how our armed forces are always on standby, throughout the year, ensuring Britain's security at home and strong abroad."
In December, the United States armed forces carried out what it called a "massive strike" on IS targets in the country, after an attack claimed the lives of two US servicemembers and a civilian interpreter in Palmyra.
The UN reports Islamic State still boasts roughly 5-7 thousand fighters in Iraq and Syria.
